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under biotechnology, we had been studied about hybridization by hybridoma technology. A German cell biologist Georges Köhler and Argentine biochemist César Milstein invent hybridoma technology in Milstein’s British Medical Research Council lab at Cambridge. Hybridomas are cells produced by the fusion of mammalian B-lymphocytes (antibody-producing cells) and myelomas (malignant bone marrow cells). Because they are cancerous, hybridoma cells can be maintained indefinitely in culture, all the while secreting antibody proteins according to the specific genetic instructions donated by the original B-lymphocyte parent. The proliferation of hybridomas is, in effect, a method of cloning antibody genes and, simultaneously, manufacturing homogenous (monoclonal) antibodies in large quantities

Note by John Rey Ciupan
2 years, 7 months ago

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