It's only another flesh wound Part 2

$\large \square\square \ - \ \square\square \ - \ \square\square$

You are given that the numbers $1,2,3,4,5,6$ are to be filled in the square boxes as shown above (without repetition) such that it represents a 2 digit integer subtracting two 2-digit integers.

Of all $6!=720$ possible arrangements, find the largest negative resultant number.

Details and Assumptions

As an explicit example, we can have $16 - 34 - 52 = -70$ and $12-53-64=-105$ as a resultant number. We will choose the formal answer of $-70$ because $-105<-70$.

See Part 1.