Marijuana and Spice

Chemistry Level 1

Tetrahydrocannabinol (THC) is the psychoactive agent in marijuana and is a partial agonist for the cannabinoid receptors. Spice is an umbrella term for synthetic compounds that work on the same receptors. Marijuana users who switch to spice experience more intense hallucinations, often becoming more dissociated and paranoid than they would with the same amount of marijuana. What is Spice when it acts on the cannabinoid receptors?

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